The characteristics and difference between Sildenaf,Tadalafil and Vardenafil



Appearance:Three raw powder both white powder

Different effect:
1.Sildenaf:Oral absorption quickly,30-120 min reach peak of blood, work within 1hour.Bioavailability is 40%.Food can significantly reduce the Sildenaf absorption rate, absorption degree and function.Sildenaf is mainly metabolized by CYP 3A4 as active metabolite in liver.
About 80% fecal excretion,13% excreted by urine,less than 0.001% of the semen.The half-life of the parent drug and the active metabolite were 4h.

2.Tadalafil:The average working time is 16 to 30 minutes,2-8 hours reach peak of blood after taking,the half-life is 44-112 hours,Prolonged half-life in renal insufficiency,even after 5 days, can still be measured in the plasma concentration of tadalafil.
Clinical report show effective rate reached 83% after taking Tadalafil,dosage is 10-20mg.The advantages are that the side effects are small, the duration is long, and the effect can be obvious in two or three days.

3.Vardenafil:The average working time is 15 to 30 minutes,the side effects are small.However, due to individual differences, there are still less than 2% of people will feel a slight headache. Soluble in water and ethanol.

The difference between customer feedback
Sildenaf :dosage is 100mg,the onset of obvious, rapid heartbeat, rapid erection of the feeling, short half-life
Tadalafil:dosage is 10-20mg ,the action time is long, the reaction is mild, the half life time is long, can reach 3 days.
Vardenafil :dosage is 10-20mg,Rapid onset, obvious effect.


Vardenafil vs Tadalafil on Treatment of ED 

Vardenafil hydrochloride Basic Info
Other names:Vardenafil
Model NO.:CAS:224785-91-5
MF:C23H33ClN6O4S
MW:525.06
Assay:99%
Form:White crystal powder
Product Categories:Steroid
Specification:GMP, ISO9001
Product Description
Anabolic steroid Raw Powder Vardenafil hydrochloride
Solubility:Soluble in alcohol and water.



Usage:For export only.The latest erectile drugs ofdysfunction (ED)  treatment field.
Storage:Keep dry place, avoid strong light and heat

Recommended dose:Suggested starting usage is 10mg ,need use it 25-60minutes before having sex.
In clinical trials, having sex to take 4 to 5 hours before, still display effect.Medication frequency limit for once a day.,not affected by eating.Need to sexual stimulation effect to make this product effect

Dose range:The dosage is from 5 to 20 mg/day, according to the constitution of different dosage.Adjust the dosage according to the different physical


Side effects:
1.Liver damage,
Child-pugh A :Don't need to adjust the dosage
Child-pugh B:As  Vardenafil's clearance to reduce, advice start from 10mg,then according to the tolerability and efficacy gradually increased to 10 mg.
Child-pugh C:Research has not yet been.Not Recommended.
2.Renal damage
Patients of mild, moderate or severe renal impairment don't need to adjust the doseage.
Vardenafil of dialysis patients pharmacokinetic research has not yet been performed.
Not Recommended.

Drug combination:
As sometimes use Vardenafil and Alpha blockers together may result in symptomatic hypotension,so
Drug combination just only applicable to patients accept alpha blockers treatment in stable condition.They start dose is 5mg.


Attention:
As having sex with a certain degree of heart risk, then dcotor should first consider his heart condition before taking any treatment on patients with erectile dysfunction.

HOT:










1. We has passed the ISO9001: 2000 (quality management system certification) ISO14001: 2004 (environmental management system certification), OHSMS (occupational health and safety system certification) three system certification, won the "Attaches great importance to contract, keep promise" and won Hubei Province Civilized units and many other honors. 

2.The company's large-scale, solid technical foundation, adequate supply,so that we can meet the different needs of various customers.

3. Professional sales team to meet the various needs of customers, customers timely answers to various questions,achieve good communication,ensure good after-sales service and solve your worries.

4.Improve the logistics system to ensure that customers will konw the movements of goods in the first time after the shipment.

5.To provide third-party product testing reports, integrity management.





Hubei Zhaoke Bio-Chemical Co., Ltd.

(Audited and gold member from 2013)