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The upcoming therapy, Rifaximin (SSD), has the potential to create a significant positive shift in the Overt Hepatic Encephalopathy market size. Topline data of Phase II study for the treatment of OHE showed treatment benefit with no significant safety concerns. Based on the results, the Phase III study is planned. 

LAS VEGAS , April 5, 2022 /PRNewswire/ -- DelveInsight's "Overt Hepatic Encephalopathy Market" report provides a thorough comprehension of the Overt Hepatic Encephalopathy historical and forecasted epidemiology and the Overt Hepatic Encephalopathy market trends in the 7MM [the United States , EU5 (Germany , Spain , Italy , France , and United Kingdom ) and Japan ]. The Overt Hepatic Encephalopathy market report also proffers an analysis of the current Overt Hepatic Encephalopathy treatment algorithm/practice, market drivers, market barriers, and unmet medical needs. 

Some of the necessary takeaways from the Overt Hepatic Encephalopathy Market Research Report 

For further information on Market Impact by Therapies, visit: Overt Hepatic Encephalopathy Drugs Market Analysis 

Hepatic encephalopathy is a brain disorder that develops in some individuals with liver disease. In Overt Hepatic Encephalopathy or Severe Hepatic encephalopathy, a person experiences impaired mental and neuro motor functioning with apparent signs of mental confusion, gross disorientation, drowsiness, and coma.

DelveInsight estimates that among 7MM, the United States had the highest diagnosed Hepatic Encephalopathy prevalent cases with 206,632 cases in 2021.

The Overt Hepatic Encephalopathy Market Analysis Report provides historical as well as forecasted epidemiological analysis segmented into: 

Get a complete epidemiological segmentation breakdown @ Overt Hepatic Encephalopathy Epidemiological Analysis

Overt Hepatic Encephalopathy Treatment Market 

The treatment of acute or persistent Hepatic Encephalopathy has changed very little during the past years. However, with newer agents under investigation, the available treatment options are supposed to increase in upcoming years. Until then, treatment options are limited to correcting or removing precipitating causes, dietary changes, and pharmacologic approaches focused on using non-absorbable disaccharides.

The two primary forms of medical therapy for Hepatic Encephalopathy are non-absorbable disaccharides (lactitol and lactulose) and non-absorbable antibiotics (Rifaximin). The hyperammonemia and inflammation due to urea breakdown in cirrhotic have led to the development of Hepatic Encephalopathy treatments that target gut bacteria. 

Unfortunately, not all patients can tolerate these agents. For patients who cannot tolerate the sweet taste of lactulose, a powder packet is available. For patients who develop gastrointestinal bloating or debilitating diarrhea, a second-line agent is considered. Xifaxan (Rifaximin) tablets (550 mg) developed and marketed by Salix Pharmaceuticals (a subsidiary of Valeant Pharmaceuticals) is approved for the reduction in risk of Overt Hepatic Encephalopathy recurrence in patients ≥ 18 years of age. Similar molecule Rifaximin (SSD) from Salix Pharmaceuticals is under clinical evaluation for the Overt Hepatic Encephalopathy treatment.

The second-line agents include oral antibiotics (neomycin, metronidazole, and rifaximin) that can reduce urease-producing bacteria in the intestines, resulting in decreased ammonia production and absorption through the gastrointestinal tract. Both neomycin and metronidazole have been used for many years to treat Hepatic Encephalopathy and are inexpensive. However, the potential side effects of neomycin (ototoxicity and renal insufficiency) and metronidazole (peripheral neuropathy) limit their use. 

The third line agents available for patients who cannot tolerate the above agents or still have persistent or episodic Hepatic Encephalopathy on the above agents are sodium benzoate, zinc, or bromocriptine. In addition, patients with unique situations may also benefit from an agent in this class. Sodium benzoate is inexpensive but is associated with a significant sodium load and gastrointestinal side effects. 

There are many key players such as Salix Pharmaceuticals/Bausch Health, Axcella Health, Inc. and several others that are developing Overt Hepatic Encephalopathy potential drugs, which are in mid and late-stage developments to be approved shortly. 

Overt Hepatic Encephalopathy Market Dynamics 

Overt Hepatic Encephalopathy Market to observe growth due to the increasing prevalent population of the disease, which will lead to a surge in treatment options. The shortfall of approved therapies might provide suitable space for emerging therapies, the clinical trial activity is not very robust, yet few novel therapies are being evaluated. Thus, the Overt Hepatic Encephalopathy market opportunity for them could be excellent. Also, medications with better safety and effectiveness, which provide an optimum cure, are the current unmet need of the Overt Hepatic Encephalopathy market; low cost and less time-consuming therapy are required in the market.

The growth of the Overt Hepatic Encephalopathy Market may be hindered by the lack of understanding of the clinical course, and clinical relevance may represent a missed opportunity to make the correct diagnosis. Also, most of the available pharmacological therapies have limited use as they only provide temporary relief. And the Overt Hepatic Encephalopathy pipeline is not very robust; more efficacious and targeted therapies are required. In addition to this, the growth of the market may hinder due to strict pricing and reimbursement policies, possible arrival of generics, and the lengthy diagnostic procedures which often lead to delayed diagnosis and unsatisfactory patient care. 

Scope of the Overt Hepatic Encephalopathy Market Insight Report 

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Overt Hepatic Encephalopathy Key Insights

Overt Hepatic Encephalopathy Report Introduction 

Overt Hepatic Encephalopathy Market Overview at a Glance 

Executive Summary of Overt Hepatic Encephalopathy

Overt Hepatic Encephalopathy Disease Background and Overview 

Overt Hepatic Encephalopathy Epidemiology and Patient Population 

Country Wise-Epidemiology of Overt Hepatic Encephalopathy 

Organizations contributing towards Overt Hepatic Encephalopathy

Overt Hepatic Encephalopathy Case Reports

Overt Hepatic Encephalopathy Patient Journey

Overt Hepatic Encephalopathy Marketed Therapies

Overt Hepatic Encephalopathy Emerging Therapies

Overt Hepatic Encephalopathy 7MM Market Analysis

The United States Overt Hepatic Encephalopathy Market Size

EU-5 Overt Hepatic Encephalopathy Market Size

The United Kingdom Market Size

Japan Overt Hepatic Encephalopathy Market Size

Overt Hepatic Encephalopathy Market Drivers

Overt Hepatic Encephalopathy Market Barriers

Overt Hepatic Encephalopathy SWOT Analysis

Overt Hepatic Encephalopathy Unmet Needs

Overt Hepatic Encephalopathy KOL Views

Browse full report with detailed TOC with charts, figures, tables @ Overt Hepatic Encephalopathy Diagnostics Market Report

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Overt Hepatic Encephalopathy - Epidemiology 

DelveInsight's Overt Hepatic Encephalopathy Epidemiology Forecast 2032 report delivers an in-depth understanding of the disease, historical, and forecasted epidemiology of Overt Hepatic Encephalopathy.

"Overt Hepatic Encephalopathy Pipeline Insight, 2022" report by DelveInsight outlines comprehensive insights of present clinical development scenarios and growth prospects across the Overt Hepatic Encephalopathy market. A detailed picture of the Overt Hepatic Encephalopathy pipeline landscape is provided, which includes the disease overview and Overt Hepatic Encephalopathy treatment guidelines. 

DelveInsight's Hepatic Encephalopathy - Market Insights, Epidemiology and Market Forecast - 2032 report provides a detailed overview of the disease and in-depth understanding of the disease,  historical and forecasted epidemiology as well as the Hepatic Encephalopathy market trends, market drivers and barriers as well as key  Hepatic Encephalopathy companies involved such as Salix Pharmaceuticals, Bausch Health, Axcella Health, Umecrine Cognition, Vedanta Biosciences, Patricia Bloom , Rebiotix, and others.

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DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.  Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.

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SOURCE DelveInsight Business Research, LLP

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